Protein Details: Intermediate conductance calcium-activated potassium channel protein 4

Protein ID

ICDB_Pro_0187

Protein Name

Intermediate conductance calcium-activated potassium channel protein 4

Gene Name

KCNN4; IK1; IKCA1; KCA4; SK4

Organism

Homo sapiens (Human)

Length

427 amino acids

AlphaFoldDB

AF-O15554-F1-model_v4.pdb

Function

Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. Plays a role in the late stages of EGF-induced macropinocytosis

Sequence

MGGDLVLGLGALRRRKRLLEQEKSLAGWALVLAGTGIGLMVLHAEMLWFGGCSWALYLFLVKCTISISTFLLLCLIVAFHAKEVQLFMTDNGLRDWRVALTGRQAAQIVLELVVCGLHPAPVRGPPCVQDLGAPLTSPQPWPGFLGQGEALLSLAMLLRLYLVPRAVLLRSGVLLNASYRSIGALNQVRFRHWFVAKLYMNTHPGRLLLGLTLGLWLTTAWVLSVAERQAVNATGHLSDTLWLIPITFLTIGYGDVVPGTMWGKIVCLCTGVMGVCCTALLVAVVARKLEFNKAEKHVHNFMMDIQYTKEMKESAARVLQEAWMFYKHTRRKESHAARRHQRKLLAAINAFRQVRLKHRKLREQVNSMVDISKMHMILYDLQQNLSSSHRALEKQIDTLAGKLDALTELLSTALGPRQLPEPSQQSK

PDB Structures

6CNM 6CNN 6CNO 6D42

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Dehydrated Hereditary Stomatocytosis 2 and Dehydrated Hereditary Stomatocytosis 1 With Or Without Pseudohyperkalemia And/Or Perinatal Edema

Location

Widely expressed in non-excitable tissues.

DOI ID

10.1073/pnas.94.20.11013; 10.1073/pnas.94.21.11651; 10.1074/jbc.272.52.32723; 10.1006/geno.1998.5333; 10.1074/jbc.m003941200; 10.1101/gr.2596504; 10.1074/jbc.274.9.5746; 10.1074/jbc.m105231200; 10.1128/mcb.25.9.3630-3638.2005; 10.1016/j.molcel.2006.11.012; 10.1073/pnas.0803678105; 10.1073/pnas.1210303109; 10.1073/pnas.1311029111; 10.1002/ajh.24117; 10.1182/blood-2015-04-642496; 10.1182/blood-2015-07-657957

RefSeq

NP_002241.1